Research progress on permeability characteristics of Chinese materia medica and evaluation approaches / 中草药

ABSTRACT

The research methods of serum pharmacology and serum biochemistry of traditional Chinese medicine isolate and identify serum transitional components from the serum of normal and disease model animals in order to find the material basis of pharmacodynamics. There are some limitations in this method for identifying the components of traditional Chinese medicine to play its pharmacological activities. Most active ingredients of traditional Chinese medicine belong to low-solubility and low-permeability drugs in the classification system of biopharmaceutics. Their bioavailability is low, but their overall biological effects are high. The classical pharmacokinetic-pharmacodynamic theory of serum pharmacology can not explain and evaluate the pharmacological effects of their non-serum transitional components. Based on the complexity of the chemical components of traditional Chinese medicine, the osmotic interaction of traditional Chinese medicine components may affect their osmotic behavior and form different oral absorption prescriptions. Therefore, the study on the permeability of traditional Chinese medicine components, especially under the condition of multi-component coexistence, is one of the topics worth to solve the problem of the functional substance basis of traditional Chinese medicine. This paper first outlines the in vitro and in vivo screening experimental models and their respective application value for the evaluation of intestinal permeability and trans-biological barrier permeability of traditional Chinese medicines. Then, the advantages and disadvantages of each model are compared, and the relationship between the structure and osmotic kinetics of common active components of traditional Chinese medicines based on osmotic model is discussed, especially the research progress of quantitative structure-kinetics relationship in permeability study of traditional Chinese medicines. Finally, based on the relationship between permeability experimental model and structure-kinetics, the recent progress in the study of multi-component osmotic dynamics and osmotic mechanism of traditional Chinese medicine is reviewed. It is found that the osmotic absorption of components can be affected by increasing or promoting drug transport or forming ion compatibility among components of traditional Chinese medicine. The prospects of its application are forecasted. In conclusion, this paper is expected to provide some references for searching and predicting the law of permeability of complex chemical constituents of traditional Chinese medicine and the mechanism of interaction between components and its application value.