A new coumarin isolated from root barks of Zanthoxylum schinifolium / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 2798-2801, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-851045
ABSTRACT
Objective:
To study the anti-inflammatory components from the root barks of Zanthoxylum schinifolium.Methods:
The compounds were isolated and purified by silica gel, MCI, Sephadex LH-20 column chromatographies, and semi-preparative HPLC, and their structures were elucidated by physical and spectroscopic analysis. The anti-inf1ammatory activity was evaluated by the levels of NO in LPS-induced RAW264.7 tested by Griess reagent.Results:
Four coumarins, namely zantholin A (1), 7-methoxycoumarin (2), isoscopoletin (3), and esculetin (4), were isolated from the root barks of Z. schinifolium. Compounds 1-4 exhibited anti-inflammatory activities on inhibition of lipopolysaccharide (LPS)-induced NO production in RAW 264.7 macrophages with IC50 values of (0.21 ± 0.03), (0.92 ± 0.16), (0.15 ± 0.02), and (0.26 ± 0.04) μmol/L, respectively.Conclusion:
Compound 1 is a new compound, a rare terpenylated coumarin named zantholin A, and compounds 3 is obtained from this plant for the first time. All compounds exhibited anti-inflammatory activities.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2019
Type:
Article
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