Chemical constituents of Artemisia argyi / 中草药

ABSTRACT

Objective: To study the chemical constituents of Artemisia argyi. Methods: The chemical constituents were isolated by silica gel column chromatography and HPLC, and its structure were identified by their spectral data and physicochemical properties analysis. Results: Thirty-four compounds were isolated from A. argyi with the structures identified as 5-hydroxy-6,7,3’,4’- tetramethoxyflavone (1), eupatorin (2), p-hydroxy-acetophenone (3), raspberry ketone (4), zingiberone (5), 7-hydroxycoumarin (6), p-hydroxybenzoic acid (7), desacetoxymatricarin (8), 3α-hydroxy-1(10),4,11(13)-triene-12,6α-olide (9), jaceosidin (10), 7-hydrxyterpineol (11), cis-2,8-dihydroxy-p-mentha-1(7)-en (12), trans-2,8-dihydroxy-p-mentha-1(7)-en (13), artemisetin (14), scopoletin (15), arteminolide C (16), desacetylmatricarin (17), artecalin (18), 11,13-dehydrodesacetylmatricarin (19), 1,9-azelaic acid (20), 3-methoxy-tanapartholide (21), phaseic acid (22), seco-guaiaretic acid (23), 5,3’,4’-trihydroxy-6,7-dimethoxy-flavone (24), 1,7-pimelic acid (25), 10-epi-ajafinin (26), 3-epi-iso-seco-tanapartholide (27), austroyunnane C (28), artanomaloide (29), ligustolide A (30), seco-tanapartholide B (31), 3-dehydroxy-iso-seco-tanapartholide (32), 3α-hydroxyreynosin (33), dihydrophaseic acid (34). Conclusion: Compounds 4, 22, 25, 30, 33, 34 are separated from the Artemisia for the first time. Compounds 5, 7, 8, 11-13, 21, 23, 24, 26-28 are isolated from A. argyi for the first time.