Molecular biological mechanism of tanshinone IIA in treatment of coronary heart disease based on network pharmacology and bioinformatics / 中草药

ABSTRACT

Objective To analyze the molecular biological mechanism of tanshinone IIA in the treatment of coronary heart disease (CHD) based on network pharmacology and bioinformatics methods. Methods The targets of tanshinone IIA were screened by uploading the chemical structure to PharmMapper database. Related targets of CHD were screened by OMIM, GeneCards, and CTD databases. The above data were imported into STRING database for PPI network analysis. Protein interaction network was constructed using Cytoscape. Gene Ontology analysis and enrichment analysis of KEGG signaling pathway were performed by Cluego. Systemsdock database was used for system molecular docking, and iGEMDOCK software was used for molecular docking to test the binding of tanshinone IIA to the targets of coronary heart disease. Results A total of 173 possible potential targets of tanshinone IIA, 42 targets related to CHD and 49 signal pathways were identified. Conclusion Tanshinone IIA has the characteristics of multi-target and multi-pathway in the treatment of CHD, and its mechanism may be through the regulation of blood pressure, cell metabolism, angiogenesis, endocrine, reactive oxygen metabolism, and other bioprocesses during the development of CHD.