Re-evaluation of Shuanghuanglian series preparations based on pharmacodynamics action value / 中草药

ABSTRACT

Objective: To re-evaluate the pharmacodynamics of Shuanghuanglian Oral Liquid, Shuanghuanglian Tablet, and Shuanghuanglian Granules with the index of pharmacodynamics action value. Methods: The pharmacodynamics action values of Shuanghuanglian Oral Liquid, Shuanghuanglian Tablet, and Shuanghuanglian Granules were determined and calculated. And the classical models of anti-inflammatory, antipyretic and antibacterial in vitro were used to verify the effect of these three preparations. Results: The pharmacodynamics action values of anti-inflammatory effect of Shuanghuanglian Oral Liquid, Shuanghuanglian Tablet, and Shuanghuanglian Granules were 2.80, 3.57, and 2.66 mg, respectively; The pharmacodynamics action values of antipyretic effect were 9.59, 14.86, and 13.42 mg respectively; The pharmacodynamics action values of antibacterial effect were 996.72, 2 011.64, and 1 691.98 mg respectively, which indicated that Shuanghuanglian Tablet had the strongest anti-inflammatory, antipyretic, and antibacterial effect, and the results of pharmacodynamics in vivo and in vitro studies also showed that Shuanghuanglian Tablet had better anti-inflammatory, antipyretic, and antibacterial effects than the other two preparations. Conclusion: In this study, the pharmacodynamic test verification results of these three preparations were consistent with the predicted results of pharmacodynamics action value. Therefore, the pharmacodynamics action value can be used as an index to re-evaluate the effect of Shuanghuanglian series preparations.