Chemical constituents from stems and leaves of Artabotrys hongkongensis / 中草药

ABSTRACT

Objective: To study the chemical constituents from the stems and leaves of Artabotrys hongkongensis. Methods: The chemical constituents of A. hongkongensis were separated and purified by silica gel, ODS, Sephadex LH-20 gel column chromatography, and preparative HPLC. Their chemical structures were identified by physicochemical properties and spectral data. Results: A total of 16 compounds were isolated from the 90% ethanol extract of the stems and leaves of A. hongkongensis, which were identified as melilotocarpan A (1), medicarpin (2), 5,7,8-trimethoxyflarone (3), 2’-hydroxy-3’,4’,6’-trimethoxychalcone (4), piperolactam C (5), uvarilactam (6), artacinatine (7), p-coumaroyl-β-phenethylamine (8), artapilosol A (9), uvarigranol B (10), 1,6-desoxypipoxide (11), 1β,11-dihydroxy-5-eudesmen (12), loliolide (13), 4-hydroxy-3-methoxybenzaldehy (14), syringlaldehyde (15), and rabdosia acid A (16). Conclusion: All compounds are isolated from A. hongkongensis for the first time. In addition to compounds 2, 7, and 9, the other compounds are isolated from the genus Artabotrys for the first time.