Effects of Hydralazine Pretreatment on Esmolol-induced Controlled Hypotension during Spine Surgery / 대한마취과학회지
Korean Journal of Anesthesiology
;
: S31-S35, 2006.
Article
in English
| WPRIM
| ID: wpr-85140
ABSTRACT
BACKGROUND:
Controlled hypotension improves surgical field and decreases transfusion requirement in surgical patients and can be induced with various kinds of drugs including esmolol and hydralazine.METHODS:
This study examined the effect of a combination of esmolol and hydralazine as hypotensive agents in spine surgery. In the esmolol group (n = 15), after boluses of esmolol (0.5 mg/kg) injection, esmolol was infused to maintain the mean arterial pressure of 55-65 mmHg. In the hydralazine-esmolol group (n = 15), hydralazine (0.3 mg/kg) was administered 15 minutes before esmolol injection which was done in the same way as that of the esmolol group.RESULTS:
The mean arterial pressure decreased to the target range more rapidly in the hydralazine-esmolol group. The heart rate was increased by hydralazine, but reduced by esmolol. The cardiac output remained elevated after hydralazine injection in the hydralazine-esmolol group, and decreased significantly by esmolol in the esmolol group. The administered dose of esmolol was much less in the hydralazine-esmolol group than in the esmolol group.CONCLUSIONS:
Our data suggest that hydralazine can enhance the efficacy of esmolol-induced controlled hypotension. It can reduce the requirement of esmolol and maintain a higher cardiac output during hypotension.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spine
/
Cardiac Output
/
Arterial Pressure
/
Heart Rate
/
Hydralazine
/
Hypotension
/
Hypotension, Controlled
Limits:
Humans
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2006
Type:
Article
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