Research progress on adriamycin nephropathy model and its pathological mechanism / 中草药

ABSTRACT

Adriamycin-induced nephritic model is one of the well-recognized models in simulating human nephropathy, whose clinical manifestations of animal models are similar to human nephrotic syndrome, and its cell models are widely used in the pathological mechanism study of nephropathy because of the well-simulated basic function of glomerular podocyte. Based on the animal models and cell models in vitro of adriamycin nephropathy, this study aims at reviewing the modelling method and pathological mechanism of adriamycin-induced nephritic model in order to provide a scientific and rational pharmacological experimental model reference for drug research and development based on kidney disease, and provide evidence for the research of the mechanism of Chinese herbal compound in the treatment of nephropathy.