New evidence supporting “intermittent pulse and severe palpitation” theory for prevention and treatment of complications of atrial fibrillation and heart failure / 中草药

ABSTRACT

The latest international clinical results show that heart failure and atrial fibrillation are two common heart diseases with extremely high coincidence. However, the existing therapeutic drugs and methods are all aimed at a single target of their respective diseases, ignoring the complex factors of complications. It is hopeful to find effective therapeutic drugs for arrhythmia and complications of heart failure from combination drugs, especially natural Chinese herbal medicines, based on the perspective of Chinese medicine. This article started with the existing clinical medicine and treatment methods for heart failure and arrhythmia, combed the traditional Chinese medicine prescriptions and single herb medicines for treating these two diseases, in which prepared licorice decoction and its derived modern Chinese medicines Wenxin Granule were systematically explored. The common targets of heart failure and arrhythmia and the prediction of the target of Wenxin Granule in the previous period were analyzed by network pharmacology, it was suggested that “intermittent pulse and severe palpitation” may be the comprehensive clinical manifestations of arrhythmia and heart failure. This article traced the origin and interpretation of the scientific connotation of “intermittent pulse and severe palpitation”.