Research progress on anticancer drugs with quercetin as lead compound / 中草药

ABSTRACT

Quercetin has the effects of anti-oxidation, prevention of cardiovascular and cerebrovascular diseases, chemical prevention, and anticancer. Because of the low bioavailability, poor water solubility, rapid metabolism, and enzyme degradation, its clinical application is limited. Due to the good solubility, high bioavailability, stable metabolism, and little the poisonous side effects, quercetin derivatives are the hot spots of the study on the modification of quercetin structure. In the last 10 years, researchers have synthesized a large number of quercetin ethers, esters, metal complexes, C-4 carbonyl oxygen substituted derivatives, and A, B ring modified compounds, and the detection of anticancer activity was conducted in vitro. In this paper, the anticancer activity of quercetin derivatives in recent 10 years is reviewed.