Quinidine-Induced QTc Interval Prolongation and Gender Differences in Healthy Korean Subjects
Korean Circulation Journal
;
: 559-566, 2007.
Article
in English
| WPRIM
| ID: wpr-85171
ABSTRACT
BACKGROUND AND OBJECTIVES:
Drug-induced electrocardiographic QT interval prolongation is associated with the occurrence of a potentially lethal form of polymorphic ventricular tachycardia, termed 'torsades de pointes' (TdP). Women are at greater risk for the development of drug-induced TdP. To determine whether this may be the result of gender-specific differences in the effect of quinidine on cardiac repolarization, we compared the degree of quinidine-induced QT interval lengthening in young, healthy volunteers. SUBJECTS ANDMETHODS:
Twelve women and 12 men each received a single intravenous dose of quinidine (4 mg/kg) or placebo in a single-blinded, randomized crossover trial. Total plasma concentrations of quinidine were measured, and QT and corrected QT intervals were analyzed.RESULTS:
As expected, the mean QTc interval at baseline was longer for women than for men (443.6+/-26.9 vs 402.1+/-31.3 msec, respectively, p=0.037). The mean value of the maximal DeltaQTc after quinidine infusion was higher in women (134.4+/-46.4 vs 117.5+/-37.7 msec, respectively, p=0.029), and the mean value of the minimal DeltaQTc for 1 hour after quinidine infusion was also higher in the female group (47.6+/-15.7 vs 83.7+/-25.4 msec, p=0.034). However, there were no significant differences in the time courses of the changes in the quinidine-induced QTc and DeltaQTc interval between the two groups (p=0.092, and p=0.305, respectively).CONCLUSION:
Quinidine causes greater QT prolongation in women at equivalent serum concentrations. This difference may contribute to the greater incidence of drug-induced TdP observed in women taking quinidine, and has implications for other cardiac and noncardiac drugs that prolong the QTc interval.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Quinidine
/
Incidence
/
Tachycardia, Ventricular
/
Asian People
/
Electrocardiography
/
Healthy Volunteers
Type of study:
Controlled clinical trial
/
Incidence study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Korean Circulation Journal
Year:
2007
Type:
Article
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