Effect of Schisandrae Chinensis Fructus powder on D-galactose-induced aging model mice / 中草药

ABSTRACT

Objective: To investigate effect of Schisandrae Chinensis Fructus powder in D-galactose-induced aging model mice. Methods: Seventy-two Kunming mice were randomly divided into normal group, model group, Naokangling group (0.810 g/kg), and low-, mid-, and high-dose (3.00, 1.50, 0.75 g/kg) Schisandrae Chinensis Fructus powder groups. Aging mice model was established by sc injection of D-galactose 1.25 g/kg at neck back once daily for 40 d. Naokangling and Schisandrae Chinensis Fructus powder were orally administrated on day 11 for 30 d. Then the learning and memory ability was assessed by step-through test on day 39. Two hours after the last administration, the contents of malonaldehyde (MDA) in brain homogenate, liver homogenate, and plasma and the activity of superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT) in whole blood were detected; The morphological changes of brain, liver, thymus, and spleen in each group of mice were observed by light microscope. Results: Compared with model groups, the Schisandrae Chinensis Fructus powder groups can improve the incubation period and reduce the number of times of light and dark shuttle of model mice; The Schisandrae Chinensis Fructus powder groups can reduce the level of MDA in plasma, brain, and liver homogenate, and increase the levels of CAT, SOD, and GSH in the whole blood in different degrees; It also can elevate the index of spleen, thymus, and brain, and decrease the indexes of liver in different degrees. Conclusion: Schisandrae Chinensis Fructus powder can significantly improve the biochemical indexes and pathological status of aging model mice.