Flavonoids of Zhuang medicine Cardiospermum halicacabum / 中草药

ABSTRACT

Objective To study the chemical constituents of Zhuang medicine Cardiospermum halicacabum. Methods The compounds were isolated and purified by silica gel, polyamide gel, and Sephadex LH-20 chromatography. The structures of the compounds were identified on the basis of chemical and spectral methods. Results Thirteen compounds were isolated from the butanol extracts of C. halicacabum and identified as chrysoeriol-7-O-β-D-glucuronide butyl ester (1), chrysoeriol-7-O-β-D- glucuronide ethyl ester (2), chrysoeriol-7-O-β-D-glucuronide methyl ester (3), chrysoeriol (4), apigenin-7-O-β-D-glucuronide butyl ester (5), apigenin-7-O-β-D-glucuronide ethyl ester (6), apigenin-7-O-β-D-glucuronide methyl ester (7), apigenin-7-O-β-D- glucuronide (8), apigenin (9), luteolin-7-O-β-D-glucuronide methyl ester (10), luteolin-7-O-β-D-glucuronide (11), luteolin (12), and quercetin (13). Conclusion Compounds 1, 2, and 3 are new flavonoiels named as cardiosperoside D, cardiosperoside B, and cardiosperoside A. Compounds 5-8, 10, and 11 are isolated from this genus for the first time.