A new antifatigue eudesmane sesquiterpenoid from Acanthopanax senticosus / 中草药

ABSTRACT

Objective To study the antifatigue bioactive constituents from Acanthopanax senticosus. Methods The compounds were isolated by means of various chromatographic techniques (Silica gel, Sephadex LH-20, MCI GEL CHP-20P, and HPLC), and its structures were elucidated by extensive spectroscopic analysis (IR, HR-MS, 1D- and 2D-NMR). The free radical scavenging activity in vitro was assessed by an ABTS assay. Results One new eudesmane sesquiterpenoid was isolated and identified as 7α(H)-eudesm-4α,5β,11,12- tetraol-3-one, and its scavenging activities towards ABTS free radical with half scavenging concentration of (43.1 ± 1.2) μg/mL. Conclusion Compound 1 is a new eudesmane sesquiterpenoid named senticosol A. Meanwhile, this compound with eudesmane skeleton is also obtained from the Araliaceae for the first time.