Hygroscopic characteristics and modification mechanism of Gubi Granules powder by multidimensional detection and low field nuclear magnetic resonance technology / 中草药

ABSTRACT

Objective To study the hygroscopic characteristics and its modification mechanism of extract spray powders of traditional Chinese medicine (TCM) compound formula, and provide basis for the key technical improvement of TCM solid preparation. Methods Gubi extract powders were taken as a model drug. The spray-drying technology was applied to Gubi water extract stock solution, water extract alcohol precipitation intermediates, and water extract alcohol precipitation intermediates containing different surfactants to get different extract powders. The microscopic pharmaceutical properties of these aboved Gubi Granules powder were characterized by powder fluidity testing and scanning electronic microscope technology; Different surfactants were adopted to study the hygroscopicity modification of water extract of alcohol precipitation intermediates, and then low field nuclear magnetic resonance technology (LF-NMR) was introduced to analyse the content, phase, distribution, and structure information of the water molecules absorbed by the modified extract powders; The mechanism of hygroscopicity modification of TCM extract powders was explored. Results ln the spray drying process of extract powders, it can improve the powder hygroscopicity by adding with PEG1000, poloxamer 188, magnesium lauryl sulfate, etc. It was analysed by LF-NMR that the above-mentioned surfactant could decrease the moisture absorption of the extract spray powder by combining with hydrophilic groups or free water in the air. Conclusion The addition of surfactants has a good effect on the hygroscopicity of TCM extract powders, and the improvement mechanism is related to the state of water combination.