Efficacy comparative analysis between part of ethyl acetate in aerial parts and roots of Astragali Radix based on metabolomics / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 2240-2247, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-851956
ABSTRACT
Objective To compare the efficacy between part of ethyl acetate in aerial parts and roots of Astragali Radix (AR), and to provide scientific evidences for the comprehensive utilization of aerial parts of Astragalus membranaceus (APAM). Methods An experimental mouse model of leucopenia was induced by cyclophosphamide, and efficacy indicators combined with NMR based on metabolomic approach were employed to compare the therapeutic effects of part of ethyl acetate in APAM and AR. Results Part of ethyl acetate in APAM and AR increased the contents of white blood cell (WBC), monocytes (MO), lymphocyte (LY), and neutrophils (NE). The levels of six potential endogenous metabolites (isoleucine, leucine, valine, arginine, creatine, and hypoxanthine) were reversed by part of ethyl acetate in APAM, and five potential endogenous metabolites (arginine, aspartate, creatine, GPC, and scyllo-Inositol) were reversed by part of ethyl acetate in AR. Efficacy indexes were 451.83 and 469.17. Conclusion Both parts of ethyl acetate in APAM and AR elevated WBC, the mechanisms of them on leukocytosis were probably related to energy metabolism, amino acids metabolism, choline metabolism, and purine metabolism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2018
Type:
Article
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