Clinical observation on Astragalus Polysaccharide Injection combined with CIK cells treating NSCLC patients with qi deficiency syndrome / 中草药

ABSTRACT

Objective: To explore the synergetic effect and observe the safety of Astragalus Polysaccharide Injection combined with cytokine-induced killer cells (CIK cells) in the treatment of advanced NSCLC patients with qi deficiency syndrome. Methods: A total of 75 advanced NSCLC patients with qi deficiency syndrome in oncology department of First Teaching Hospital of Tianjin University of TCM enrolled in the study were randomized into two groups the control group (CIK cells group) and the combined group (Astragalus Polysaccharide Injection + CIK cells group) by the random number table method. The control group CIK cells were transfused in vein (100 mL each time, once every Monday, Wednesday, and Friday, five times in total, the total number of cells > 1× 1010/mL). The combined group CIK cells treatment combined with astragalus polysaccharide injection intravenous drip (250 mg Qd, 10 d). Ten days is one cycle, both groups were received the second cycle treatment in a month later. Results: The combined group's disease control rate (DCR=CR + PR + SD) was 69.4%, higher than that of control group's (36.1%), and the difference was statistically significant (P < 0.05).The KPS of combined group's effective rate was 77.8%, higher than 55.6% in the control group, the difference was statistically significant (P < 0.05). After treatment, shortness of breath, spiritlessness, hypodynamia, spontaneous perspiration and speaking reluctantly had taken a turn for the better in combined group, especially in spiritlessness, hypodynamia, spontaneous perspiration, gospeaking reluctantlyt to improve obviously, and the difference was statistical significance (P < 0.05). The haematologic toxicity in II, III, IV degree and hepatic and renal toxicity in III, IV degree did not appear in two groups. Conclusion: The Astragalus Polysaccharide Injection combined with CIK cells could control tumor lesion's progress, and improve the patient's immune function, the symptom of qi deficiency syndrome, and body functional status due to itsbetter security.