Current research situation of Buyang Huanwu Decoction and its development of new medical invention / 中草药

ABSTRACT

Buyang Huanwu Decoction (BHD) is a famous prescription for treating cerebral ischemia stroke with qi deficiency and blood stasis syndrome. More than 500 pieces of papers were reported about this prescription each year, including the medicinal resources, material bases, pharmaceutical, pharmacological effects, clinical application, preparation reform and so on, which showed the prescription research was broad and profound. Due to the complex constituents of this prescription, currently the network pharmacologic topologic method is difficult to illuminate the material basic and pharmacological mechanism of BHD. This paper has systematically sorted and analyzed BHD related research work for nearly ten years, mainly summarized pharmacy, pharmacology, and toxicology, thereby to put forward the present key problems to be solved immediately for creating a constituent Chinese medicine or natural compound medicine. Meanwhile, combined with the previous researches of quantitative network chromatopharmology, compared with the present medicine-marketed molecular structure main in treatment of ischemic stroke, intends to discuses critical technical problems of the material bases, the connection affirmation of effective ingredients and targets etc, in order to find out solution strategy and to lay a foundation for further development of a new constituent Chinese medicine or natural compound medicine.