Pharmacokinetics and tissue distribution of usnic acid phospholipid complex in rats / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1358-1364, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-852111
ABSTRACT
Objective:
To study pharmacokinetics and tissue distribution of usnic acid phospholipid complex (UAPC) in rats by oral administration.Methods:
HPLC was established for determination of usnic acid (UA) in the rat plasma and tissue. Rats were ig administrated UA suspension and UAPC (35.0, 17.5, and 11.7 mg/kg, with UA count). The concentrations of UA in plasma and tissue were determined by HPLC at the different time points. The pharmacokinetic parameters were calculated by the DAS 2.0 software.Results:
Compared with the administration of UA, the main pharmacokinetic parameters of UAPC Cmax, AUC0-t of UAPC increased significantly (P 0.05) after ig administrations of UAPC at a dose of 11.7 mg/kg, the relative bioavailability of UAPC was 109.67%. The tissue distribution of UAPC UAPC was distributed more in the liver, spleen and brain at a dose of 35 mg/kg; UAPC was distributed more in the lung and brain at a dose of 17.5 mg/kg; And UAPC was distributed more in the liver and kidney at a dose of 11.7 mg/kg.Conclusion:
Phospholipid complex improve the oral bioavailability of UA, and change the distribution in the tissue of rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2018
Type:
Article
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