Study on spectrum-effect relationship among effects of different extracts of Crataegi Folium on whole blood viscosity in rats / 中草药

ABSTRACT

Objective: To study the correlation between the fingerprints of different extracts of Crataegi Folium and reducing the blood viscosity of blood stasis rats, and to provide a theoretical basis and data support for the establishment of the quality control model of traditional Chinese medicine, which is "Fingerprints are associated with efficacy". Methods: Fingerprints of different extracts of Crataegi Folium were established by high performance liquid phase method. The multivariate linear regression equation of common peak X and whole blood viscosity Y was calculated by stepwise regression analysis of MATLAB software. Results: There were 32 common peaks in the fingerprints, X9, X10, X11, X13, X14, X15, X17, X19, X27, and X29 related to the whole blood viscosity Y compose functional composition groups. X10, X11, X13, X19, X29 negatively correlated with Y, which may be active monomer components, among which X14 is vitexin glucoside, X17 is Vitexin, and X19 is rutin. Conclusion: The multiple regression equation calculated by MATLAB statistical software in this study has significance in statistics, which can provide a scientific basis for further study of the active components of Crataegi Folium extract.