Optimization of extraction process route of Compound Huangqi Water Extract based on fuzzy analytic hierarchy process evaluation model / 中草药

ABSTRACT

Objective To optimize extraction process route of Compound Huangqi Water Extract by using fuzzy analytic hierarchy process (FAHP). Methods The multi-level index evaluation model was established and divided into target layer, criterion layer and index layer. The criterion layer included indicative components and pharmacodynamics index. The index layer consisted of transfer rate of astragaloside and geniposidic acid, volume of ascites, content of VEGF in ascites and thymus index. All the indexes were weighted by using FAHP, and the comprehensive score of each extraction process route was obtained. Results The important degrees (w) of each index from high to low were volume of ascites (w = 0.255), content of VEGF in ascites (w = 0.215), thymus index (w = 0.200), transfer rate of Astragaloside (w = 0.170), and transfer rate of geniposidic acid (w = 0.160). The scores from high to low were route a > route c > route b. Hence, the optimized extraction process route of Compound Huangqi Water Extract was reflux extraction with water. Conclusion This experiment combined chemical index and pharmacodynamics index as evaluation index. Weighting coefficient of all the indexes was decided by FAHP-based evaluation. It can provide research ideas and methods for optimizing extraction process of clinical empirical formula in the development of patent medicine.