Degradation of total saponins of Panax notoginseng by intestinal flora of rats in vitro / 中草药

ABSTRACT

Objective To investigate the degradation of three kinds of saponins (notoginseng saponin R1, ginsenoside Rg1, and ginsenoside Rb1) from total saponins of Panax notoginseng (tPNS) by intestinal flora in male and female rats in vitro. Methods tPNS were incubated for 24 h with male and female rats intestinal flora separately in vitro under anaerobic environment. The content of three kinds of saponins was measured at different treatment time. Results The results showed that the intestinal flora both in male and female rats all had the degradation action against ginsenosides Rb1, in which the degradation of male rats was slightly faster than that of female rats. But the intestinal flora both in male and female rats had no obvious degradation to notoginseng saponin R1 and ginsenoside Rg1. Conclusion Under the condition of in vitro, tPNS can be degraded by rats intestinal flora, of which Rb1 was degraded most, while notoginseng saponin R1 and ginsenoside Rg1 were more stable.