Effect of Radix Astragali and Aconiti Lateralis Radix Preparata on intestinal absorption of six kinds of alkaloids in Aconiti Lateralis Radix Preparata / 中草药

ABSTRACT

Objective To study the effect of Radix Astragali and Aconiti Lateralis Radix Preparata on the intestinal absorption of the three kinds of monoester-type alkaloids (benzoylthioate, benzoyl neostearine, and benzoyl aconitine) and three kinds of diester-type alkaloids (hypaconitine, neaconitine, and aconitine) in Aconiti Lateralis Radix Preparata. Methods The rat duodenum, the jejunum, and the ileum were selected to study the intestinal segment. The apparent permeability coefficient (Papp) was used to evaluate the effect of Radix Astragali on the Papp of six kinds of alkaloids in Aconiti Lateralis Radix Preparata. Results When Aconiti Lateralis Radix Preparata and Radix Astragali was 31, Radix Astragali can significantly reduce the dipeptide alkaloid Papp in the duodenum and ileum and reduce the monoester-type alkaloid Papp in three kinds of intestinal segments; When Aconiti Lateralis Radix Preparata and Radix Astragali was 11, except in the ileum, Radix Astragali can significantly reduce the Papp of the diester-type alkaloid; When Aconiti Lateralis Radix Preparata and Radix Astragali was 13, Radix Astragali can significantly reduce the Papp of the monoester-type alkaloid (except the parenteral) and significantly reduced the Papp of the three diester-type alkaloids. Conclusion Radix Astragali can inhibit the absorption of aconite alkaloids, and its inhibition effect is different due to different compatibility ratios, types of alkaloids and intestinal segments.