Protective effects of essential oil of Uygur medicine rose on acute myocardial ischemia injury in mice / 中草药

ABSTRACT

Objective To study the protective effect of rose (Rosae Rugosae Flos) essential oil on acute myocardial infarction in mice, and explore its mechanism. Methods The model of acute myocardial ischemia in mice was established by intraperitoneal injection of isopropyl adrenaline. The myocardial tissue pathological changes and the degree of myocardial injury in mice were observed by HE staining and TTC staining. Activities of super oxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in myocardial tissue of mice were determined, and activities of creatine kinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH) in serum of mice were determined as well. Results HE staining results showed that rose essential oil group (160, 80, and 40 mg/kg) can significantly improve myocardial tissue pathological injury in mice; TTC staining results showed rose essential oil (160, 80, and 40 mg/kg) can significantly reduce the myocardial ischemia areas in mice. Compared with model group, SOD and GSH-Px in the myocardial tissue of mice significantly increased (P < 0.05, 0.01), while enzyme activity of serum LDH and CK-MB significantly reduced in rose essential oil group (P < 0.05, 0.01). Conclusion Rose essential oil has certain protective effect on acute myocardial infarction injury and its mechanism may be associated with inhibiting oxidative damage, enhancing activities of anti-oxidant enzymes, and reducing the lipid peroxidation damage.