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The immunohistochemical study on Ki-67 Expression in epithelial ovarian carcinomas / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology ; : 1288-1294, 2008.
Article in Korean | WPRIM | ID: wpr-85240
ABSTRACT

OBJECTIVE:

The study was to evaluate the biological significance of Ki-67 expression in common epithelial ovarian carcinomas. We investigated the correlation between Ki-67 expression and clinicopathological parameters.

METHODS:

One hundred patients with epithelial ovarian carcinomas stage I-IV treated at Department of Obstertrics and Gynecology, Korea University Hospital from January 1994 to December 2004 were used as study group. We determined expression of Ki-67 by immunohistochemistry using MIB-1 monoclonal antibody reactivity.

RESULTS:

Ki-67 overexpression was higher in high stage (III-IV) than low stage (I-II) (P<0.013). Ki-67 overexpression was higher in serous cystadenocarcinoma (76.3%) than mucinous cystadenocarcinoma (53.6%), endometrioid carcinoma (54.5%) and clear cell carcinoma (58.3%) but it was not statistically significant (P<0.191). Ki-67 expression was higher in high grade but it was not statistically significant (P<0.096). Ki-67 overexpression was not correlated with serum CA-125 level (P<0.172). Overall survival revealed significant survival difference between patients whose tumor showed Ki-67 overexpressions compared with remaining patients.

CONCLUSIONS:

Ki-67 overexpressions was a poor prognostic indicator in epithelial ovarian carcinomas.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Ovary / Immunohistochemistry / Antibodies, Antinuclear / Cystadenocarcinoma, Serous / Cystadenocarcinoma, Mucinous / Carcinoma, Endometrioid / Ki-67 Antigen / Gynecology / Korea / Antibodies, Monoclonal Type of study: Prognostic study Limits: Female / Humans Country/Region as subject: Asia Language: Korean Journal: Korean Journal of Obstetrics and Gynecology Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Ovary / Immunohistochemistry / Antibodies, Antinuclear / Cystadenocarcinoma, Serous / Cystadenocarcinoma, Mucinous / Carcinoma, Endometrioid / Ki-67 Antigen / Gynecology / Korea / Antibodies, Monoclonal Type of study: Prognostic study Limits: Female / Humans Country/Region as subject: Asia Language: Korean Journal: Korean Journal of Obstetrics and Gynecology Year: 2008 Type: Article