The immunohistochemical study on Ki-67 Expression in epithelial ovarian carcinomas / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 1288-1294, 2008.
Article
in Korean
| WPRIM
| ID: wpr-85240
ABSTRACT
OBJECTIVE:
The study was to evaluate the biological significance of Ki-67 expression in common epithelial ovarian carcinomas. We investigated the correlation between Ki-67 expression and clinicopathological parameters.METHODS:
One hundred patients with epithelial ovarian carcinomas stage I-IV treated at Department of Obstertrics and Gynecology, Korea University Hospital from January 1994 to December 2004 were used as study group. We determined expression of Ki-67 by immunohistochemistry using MIB-1 monoclonal antibody reactivity.RESULTS:
Ki-67 overexpression was higher in high stage (III-IV) than low stage (I-II) (P<0.013). Ki-67 overexpression was higher in serous cystadenocarcinoma (76.3%) than mucinous cystadenocarcinoma (53.6%), endometrioid carcinoma (54.5%) and clear cell carcinoma (58.3%) but it was not statistically significant (P<0.191). Ki-67 expression was higher in high grade but it was not statistically significant (P<0.096). Ki-67 overexpression was not correlated with serum CA-125 level (P<0.172). Overall survival revealed significant survival difference between patients whose tumor showed Ki-67 overexpressions compared with remaining patients.CONCLUSIONS:
Ki-67 overexpressions was a poor prognostic indicator in epithelial ovarian carcinomas.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovary
/
Immunohistochemistry
/
Antibodies, Antinuclear
/
Cystadenocarcinoma, Serous
/
Cystadenocarcinoma, Mucinous
/
Carcinoma, Endometrioid
/
Ki-67 Antigen
/
Gynecology
/
Korea
/
Antibodies, Monoclonal
Type of study:
Prognostic study
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2008
Type:
Article
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