Research progress on feedforward control strategy and its application prospect in quality control of Chinese materia medica / 中草药

ABSTRACT

As a widely applied process control strategy in chemical industry, the feedforward control strategies have been applied in pharmaceutical manufacturing to reduce the quality fluctuation of drugs. The application of feedforward control strategy in the manufacturing of Chinese materia medica (CMM) can help us to understand the relationship between input material attributes, process parameters and critical quality attributes (CQAs), and then to establish an optimal model for the adjustment of process parameters based on input material attributes with the aim of minimizing the variation of CQAs. Before the production of the new batch, the most suitable process parameters for the input materials can be calculated by the optimal model. The motivation of this paper is to provide an overview of recent research on application of feedforward control strategies in pharmaceutical manufacturing and demonstrate perspectives of their application in CMM.