Study on mechanisms of Liujing Toutong Tablets in treatment of migraine by network pharmacology / 中草药

ABSTRACT

Objective To study the mechanisms of Liujing Toutong Tablets (LTT) in the treatment of migraine by network pharmacology. Methods Eighteen components of LTT absorbed into blood were selected as the objects, and targets of compounds were predicted according to the reverse pharmacophore matching method. The related pathways and correlation analysis were explored by the MAS 3.0 biomolecule function software and the Kyoto Encyclopedia and Genomes (KEGG) database. Finally, the network of compound-target-pathway-disease of LTT was constructed by Cytoscape software. Results Eighteen compounds interacted with 88 pathways through 72 targets, of which 36 protein targets and 22 pathways were associated with migraine. Conclusion LTT may play a role in expelling wind and dredging collaterals, promoting orifice and pain-relieving by intervening with the related pathways of inflammation, homeostasis of blood vessels, nervous centralis, immunity, and hormonal regulation.