Effects of Liujing Toutong Tablets on isolated vascular smooth muscle and expression of calcitonin gene-related peptide in trigeminus / 中草药

ABSTRACT

Objective To investigate the effects of Liujing Toutong Tablets (LTT) on isolated vascular smooth muscle and the expression of calcitonin gene-related peptide (CGRP) in trigeminus. Methods Rats’ thoracic aorta and trigeminus were isolated to investigate the exact effect by measuring the contractile response of vascular and the expression of CGRP in trigeminus. Results The LTT could reduce the quantity of positive CGRP cells expressed in trigeminus (P < 0.05) and weaken the contractile response of thoracic aorta induced by KCl and NE, and the IC50 is 0.97 mg/mL and 0.55 mg/mL, respectively. Conclusion LTT could inhibit contractile response of vascular smooth muscle, meantime, reduce the quantity of positive CGRP cells expressed in trigeminus. The results show that LTT can stabilize vascular systaltic property.