Research progress on intervention of traditional Chinese medicine on coronary heart disease through PI3K/Akt signaling pathway / 中草药

ABSTRACT

Phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB/Akt) signaling pathway can regulate cell growth, metabolism, and apoptosis, which has a wide range of biological effects. It participates in the pathogenesis of various diseases such as cancer, coronary heart disease, and metabolic disorders, and it is an important target for treatment. In recent years, the role of PI3K/Akt signaling pathway in the development of coronary heart disease has been increasingly paid attention. The relationship between the structural features of PI3K/Akt and the development of coronary heart disease and the intervention of traditional Chinese medicine is summarized to provide a reference for the development of coronary heart disease treatment.