Chemical constituents from anti-inflammatory and analgesic active fraction of Gaultheria leucocarpa var. yunnanensis / 中草药

ABSTRACT

Objective To study the chemical constituents from anti-inflammatory and analgesic active fraction (ARF) of Gaultheria leucocarpa var. yunnanensis. Methods The compounds were isolated and purified by various techniques of column chromatography, and their structures were determined according to physicochemical properties and spectral analyses. Results Sixteen compounds were obtained and identified as methyl salicylate 2-O-β-D-glucopyranoside (1), gaultherin (2), MSTG-A (3), MSTG-B (4), ethyl-O-β-D-xylopyranoside (5), ethyl-O-β-D-xylopyranosyl (1→6)-O-β-D-glucopyranoside (6), methyl-O-β-D-xylopyranosyl (1→6)-O-β-D-glucopyranoside (7), roseoside (8), paeoniflorin (9), vanillic acid (10), 2,5-dihydroxybenzoic acid (11), 3,4-dimethoxycinnamic acid (12), ferulic acid (13), chlorogenic acid (14), 4-hydroxy-2,6-dimethoxyphenol-O-β-D-glucopyranoside (15), and 3-methoxyl-1H-pyrrole (16). Conclusion Compounds 5-9, 12, 15, and 16 are obtained from this plant and compound 7 is isolated from the plants of genus Gaultheria Kalm ex L. for the first time. Compounds 8, 9, 12, and 15 are obtained from family Ericaceae for the first time.