Chemical constituents of endophytic fungus Phomopsis sp. YK-7 isolated from Tetrastigma hemsleyanum / 中草药

ABSTRACT

Objective: To study the chemical constituents of endophytic fungus Phomopsis sp. YK-7 isolated from Tetrastigma hemsleyanum. Methods: The compounds were isolated and purified by chromatographic techniques and their structures were identified on the basis of spectral features. Results: Fifteent known compounds, including 13 arylbenzofuran derivatives and two steroids, named wittifuran X (1), 4-hydroxy-2-(4'-hydroxy-2'-methoxyphenyl)-6-methoxybenzofuran-3-carbaldehyde (2), erypoegin J (3), moracin S (4), moracin T (5), moracin C (6), wiffifuran E (7), iteafuranal A (8), burttinol D (9), 7-methoxy-2-(4-methoxyphenyl)-3- methyl-5-(3-prenyl)-benzofuran (10), moracin N (11), moracin P (12), moracin M (13), ergosterol peroxide (14), and 25-hydroxy- ergosta-4,6,8(14),22-tetraen-3-one (15) were isolated from the fermentation products of Phomopsis sp. YK-7. Conclusion: Compounds 1-9 are obtained from genus Phomopsis for the first time.