Advances on Chinese materia medica-chemical drug interactions mediated by P-glycoprotein / 中草药

ABSTRACT

Chinese materia medica (CMM) in combination with chemical drug is an effective treatment for diseases. CMM sustain moderate effect, including multiple components, multiple targets, multiple pathways and integrated regulation characteristics; While the effect of chemical drug is rapid and shows definite target and single way, the combination of the two can be complementary advantages, synergistic effects and reduce toxicity. P-glycoprotein (P-gp) is a kind of energy dependent transmembrane transport protein; Its mediated efflux effect is one of important targets for drug delivery. The induction or inhibition of P-gp plays a significant factor in the interaction generated when CMM and chemical drug combined application. In this paper, interaction of CMM combined with chemical drug in P-gp level was briefly reviewed, in order to reveal the role of P-gp in joint use Chinese and Western medicine, and to provide reference for the rational use of drugs to integration of Chinese and Western medicine in clinic.