Identification of in vivo substances of rats after oral administration of mulberry leaves flavonoids by uplc-q-tof/ms / 中草药

ABSTRACT

Objective To identify the chemical substances in plasma, urine, feces and bile samples of rats after oral administration of mulberry leaves flavonoids. Methods The plasma, urine, feces and bile samples of rats after a single oral administration of mulberry leaves flavonoids at a dose of 0.5 g/kg at different time points were detected by UPLC-Q-TOF/MS. Results Thirteen prototype compounds and 41 metabolites were found. The metabolites mainly included glucuronidation, sulfation and methylation. Conclusion This reseach estabilished the basis to study the pharmacokinetics and the pharmacological action mechanism of the mulberry leaves.