Pharmacokinetics study on evodiamine-curcumin nanoparticles / 中草药

ABSTRACT

Objective To investigate the in vivo pharmacokinetic characteristics of evodiamine-curcumin nanoparticles (ECNP), and to discuss the influence of curcumin (CUR) to the bioavailability of evodiamine (EVO). Methods ECNP were prepared by solvent evaporation method. Rats were orally given ECNP. After administration, blood samples were collected from the retinal venous plexus of SD rats at different time points. And the blood concentration of EVO was determined by HPLC. Results The AUC0-t of ECNP, mixture of evodiamine and curcumin (MEC) and free EVO were (3 197.74 ± 81.64) μg∙h/L, (1 387.73 ± 39.42) μg∙h/L, and (928.08 ± 54.84) μg∙h/L, respectively. The AUC0-t of MEC was 1.50 times as free EVO. The AUC0-t of ECNP was 3.45 and 2.30 times as EVO and MEC, respectively. Conclusion The absorption of EVO in rats was promoted with CUR, and nanoparticles can further improve the oral bioavailability of EVO in rats.