Optimization of microwave processing technology for carbonized Gardenia jasminoides by Box-Behnken response surface methodology based on CRITIC weighted evaluation / 中草药

ABSTRACT

Objective: To determine the index weight and optimize the microwave processing technology of carbonized Gardenia jasminoides (CGJ). Methods: The contents of geniposid and tannins in CGJ processed by traditional method were determined by HPLC and used as comprehensive evaluation indexes, the weighting coefficient was determined by CRITIC method, and the microwave processing technology of CGJ was optimized by Box-Behnken response surface methodology (BBRSM). The pharmacological activity of CGJ processed by microwave was also evaluated. Results: The weighting coefficients of geniposid and tannins in CGJ processed by traditional method were 0.27 and 0.73. The optimal parameters of microwave processing technology were as follows: microwave power of 600 W, microwave time of 6 min and medicines mass of 120 g, the contents of geniposidic and tannins were 35.19 and 4.76 mg/g. The results of pharmacological evaluation showed that CGJ processed by microwave and traditional method could shorten the bleeding time and clotting time of mice. There was no obvious difference between the two processed products. Conclusion: Microwave processing can be used as a processing method to enrich the traditional processing technology.