Studies on non-alkaloid constituents from Ochrosia elliptica (II) / 中草药

ABSTRACT

Objective: To study the non-alkaloid constituents from stems and leaves of Ochrosia elliptica. Methods: The chemical constituents from O. elliptica were separated and purified by silica gel, ODS, Sephadex LH-20 gel column chromatography, and preparative HPLC. Their structures were identified by physicochemical properties, spectroscopic analysis, as well as comparisons with the data in literature. Results: Fifteen compounds were isolated from the ethyl acetate fraction of 90% ethanol extract from O. elliptica, which were identified as hedyotisol A (1), (-)-(7R,7'R,7″S,8S,8'S,8″S)-4',4″-dihydroxy-3,3',3″,5-tetramethoxy-7,9',7',9-diepoxy-4,8″-oxy-8,8'-sesquineolignan-7″,9″-diol (2), 8-hydroxypinoresinol (3), lyoniresinol (4), balanophonin (5), formononetin (6), vestitol (7), mucronulatol (8), (3R)-violanone (9), 6-hydroxy-2-(2-phenylethyl) chromone (10), 6-hydroxy-2-[2-4'-(methoxyphenyl) ethyl] chromone (11), 4-hydroxyacetophenone (12), dehydrovomifoliol (13), loliolide (14), and 4,5-dihydroblumenol A (15). Conclusion: All compounds are isolated from the genus Ochrosia Juss. for the first time.