Screening of active components of Jitongning Tablet by liposome equilibrium dialysis and LC-MS analysis / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 668-672, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-852969
ABSTRACT
Objective:
To explore the interaction between the effective components of Jitongning Tablet (JT) and liposome biomembrance, in order to predict in vivo absorption of the effective components.Methods:
Liposome as the model of biomembrance, active components were screened by liposome equilibrium dialysis and LC-MS; And the effect of experiment conditions on the interaction of the liposome concentration, and the pH value of buffer were also investigated.Results:
There were 11 compounds in JT with obvious interaction with liposome, including 4 flavonoids, 2 triterpenoid, 4 coumarins, and 1 phenylpropionic acid. The concentration of liposome and pH value of buffer remarkably affected the interaction between JT and liposome.Conclusion:
The established method contributes to predicting the multiple components absorption in body, indicating the potentially active compounds and providing reference for further research of pharmacodynamic substance basis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2017
Type:
Article
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