Isolation and antifungal activities of a pair of isomers of phloroglucinol derivatives from Dryopteris fragrans / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 433-436, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-852994
ABSTRACT
Objective:
To study the chemical constituents and antifungal activitiy of phloroglucinol derivatives from Dryopteris fragrans.Methods:
The phloroglucinol derivatives were isolated by silica gel column chromatography, Sephadex LH-20 column chromatography, and pre-HPLC. The chemical structures were elucidated on the basis of physicochemical and spectral properties. The antifungal activities against Trichophyton rubrum and Microsporum gypseum were tested by CLSI M38-A2 broth microdilution methods.Results:
Two phloroglucinol derivatives were isolated and identified as disflavaspidic acid PB (1) and flavaspidic acid PB (2). The minimum inhibitory concentration (MIC) of compounds 1 and 2 were 13.33 and 1.875 μg/mL against T. rubrum respectively, 10 and 1.325 μg/mL against M. gypseum.Conclusion:
Compound 1 is a new compound named disflavaspidic acid PB. Compound 2 is isolated from D. fragrans for the first time. Compounds 1 and 2 are a pair of isomers with promising antifungal activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2017
Type:
Article
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