Effects of baicalein on D-galactose-induced aging rats based on 1H-NMR metabonomics / 中草药

ABSTRACT

Objective: To explore the intervention of baicalein on D-galactose-induced aging rats by 1H-NMR metabonomics methods. Methods: The aging model was induced by sc injection of D-galactose (150 mg/kg) in rats, and the effects of baicalein (50, 100, and 200 mg/kg) on autonomic activities of aging rats were investigated. After 10 weeks, the serum of rats was collected for 1H-NMR detection, and the anti-aging effects of baicalein were explored using multivariate statistical analysis. Results: Baicalein significantly improved the locomotor activities of aging rats. Compared with control group, the levels of alanine, acetic acid, pyruvic acid, tyrosine, and N-acetyl glycoproteins in rat serum of model group increased, while the levels of glutamine, dimethyl glycine, glycine, threonine, creatinine, and histidine decreased. These 11 potential biomarkers could be reversely regulated after treatment with baicalein. Conclusion: Baicalein exerts anti-aging effects likely through regulation of amino acid metabolism, nucleotide metabolism, and glucose metabolism.