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Effects of Cilostazol on Platelet Activation in Coronary Stenting Patients Who Already Treated with Aspirin and Clopidogrel
The Korean Journal of Internal Medicine ; : 230-236, 2004.
Article in English | WPRIM | ID: wpr-85304
ABSTRACT

BACKGROUND:

A recent study has shown that triple anti-platelet therapy (cilostazol+clopidogrel+aspirin) resulted in a significantly lower restenosis rate after coronary stenting than did conventional therapy (clopidogrel+aspirin). However, the anti-platelet effects of cilostazol, when combined with clopidogrel and aspirin, have not been evaluated.

METHODS:

Low dose cilostazol (50 mg/BID) was given to 47 patients who had already been taking clopidogrel (75 mg/day) and aspirin (100 mg/day) for more than 1 month subsequent to coronary stenting due to AMI and unstable angina. Markers of platelet activation, P-selectin and activated GPIIb/IIIa on platelets, were measured at baseline and 2 weeks after cilostazol treatment. We empirically divided patients into tertiles (low, n=16; moderate, n=14; high group, n=17), according to the baseline P-selectin expression. We then performed a comparative assessment of the anti-platelet effects of cilostazol at baseline and after 2 weeks of cilosatzol administration.

RESULTS:

P-selectin was significantly decreased after 2 weeks of cilostazol treatment in total patients (n=47, 3.2 +/- 2.4% to 2.0 +/- 1.9%, p=0.03). This inhibition of P-selectin expression was mainly achieved in the moderate and high P-selectin groups (low group; 1.4 +/- 0.5 to 1.9 +/- 1.3%, p> 0.05, moderate group; 2.5 +/- 0.3 to 1.3 +/- 0.3%, p 0.05). Underlying disease, cardiovascular risk factors, concomitant medication including statin, and hsCRP were not related to the degree of P-selectin expression.

CONCLUSION:

Our data demonstrated that cilostazol treatment in addition to conventional anti-platelet therapy provides more effective suppression of platelet P-selectin expression in patients with relatively high platelet activity.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Tetrazoles / Thrombosis / Ticlopidine / Platelet Aggregation Inhibitors / Stents / Aspirin / Myocardial Ischemia / Platelet Glycoprotein GPIIb-IIIa Complex / P-Selectin / Dose-Response Relationship, Drug Type of study: Risk factors Limits: Female / Humans / Male Language: English Journal: The Korean Journal of Internal Medicine Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tetrazoles / Thrombosis / Ticlopidine / Platelet Aggregation Inhibitors / Stents / Aspirin / Myocardial Ischemia / Platelet Glycoprotein GPIIb-IIIa Complex / P-Selectin / Dose-Response Relationship, Drug Type of study: Risk factors Limits: Female / Humans / Male Language: English Journal: The Korean Journal of Internal Medicine Year: 2004 Type: Article