Research progress in Polygonati Rhizoma and predictive analysis on Q-marker / 中草药

ABSTRACT

Polygonati Rhizoma (PR) is a traditional Chinese herbal medicine, mainly distributed in the North Temperate Zone and North Subtropical Zone, widely spread over the south China. As the progress of PR in pharmacology, medicinal chemistry, and clinical research, the study of Polygonatum's active site and effective components are attached much attention in new drug research and development. In this paper, the resources, chemical composition, pharmacological activity, and clinical application of PR are summarized. Literature research suggests a variety of chemical composition in PR, including polysaccharide, steroidal saponins, terpene, alkaloid, wooden fat element, flavonoids, and phytosterols, in which polysaccharides and steroidal saponins class are the main efficacy components. On the base, the difference of the main chemical composition are compared in P. sibiricum, P. kingianum and P. cyrtonema, to provide experiment basis for Q-maker determining; And the contribution of polygonatum polysaccharide, steroidal saponins and isoflavone compounds to the main therapeutic effects were been studied. It is suggested to carry out the quality standard and Q-marker research in PR-the qualitative and quantitative analysis of polysaccharide, steroidal saponins and isoflavone compounds in the high quality PR and compare the quantitative limit of different batches, to provide scientific data for quality standard setting.