Research progress in inhibition of Chinese materia medica with breaking blood stasis and resolving mass on tumor metastasis / 中草药

ABSTRACT

Activating blood and dissolving stasis is one of the important principles of clinical anti-tumor by traditional Chinese medicine and the anti-tumor effect of the blood-activating and stasis-resolving drugs has been confirmed by a large number of studies. But in recent years, some experimental studies have found that some blood-activating and stasis-resolving drugs could promote tumor metastasis. And then the clinical application of this kind of drugs has suffered from many controversial problems. Chinese materia medica (CMM) with breaking blood stasis and resolving mass (Poxue herbs) is a kind of blood-activating and stasis-resolving drugs which display the severe effect. Nowadays some researchers confirmed its obvious antineoplastic effect and its prominent anti-tumor metastasis effect, which indicated in recent studies. In this article, we summarized the anti-tumor metastasis effect and mechanism of the Poxue herbs like Curcumae Rhizoma, Sparganii Rhizoma, large blister Beetle, leech, and its effective components in detail. And we also put forward that Poxue herbs are the ones which have the anti-tumor metastasis effect among blood-activating and stasis-resolving drugs, and it valued with significant clinical application and development. It is also believed that the Poxue herbs could inhibit the tumor metastasis which is related with aerobic glycolysis and can provide the theoretical direction to guide clinical application.