Study on active constituents from Glycyrrhizae Radix et Rhizoma against NO production in LPS-induced RAW264.7 macrophages / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 4155-4159, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-853120
ABSTRACT
Objective:
To study the anti-inflammatory constituents in Glycyrrhizae Radix et Rhizoma.Methods:
The compounds were isolated and purified by means of macroporous resin, ODS column chromatography, and semi-preparative HPLC. And their structures were identified by LC-MS, 1H-NMR, and 13C-NMR. The anti-inflammatory activities of the compounds were evaluated on LPS-induced NO production in RAW 264.7 macrophages.Results:
Their structures were identified as liquiritin (1), liquiritin apioside (2), isoliquiritin (3), isoliquiritin apioside (4), sophoraisoflavone A (5), glyasperin F (6), glabrone (7), glabridin (8), licoflavonol (9), and glyasperin D (10).Conclusion:
Compounds 1, 3, 5, 6, 8, and 9 could inhibit NO production in RAW 264.7 macrophages to some extent. And the anti-inflammatory effects of compounds 5, 6, and 9 are first reported in this work.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2016
Type:
Article
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