Effectivity and safety of Yaotongning Capsules in treatment of lumbar discherniation with cold dampness and blood stasis syndrome: A randomized blind controlled and multicenter trial / 中草药

ABSTRACT

Objective: To evaluate the efficacy and safety of Yaotongning Capsules in the treatment of lumbar disc herniation (cold dampness and blood stasis syndrome). Methods: This research was carried out using stratified random method, blind, positive drug controlled, and multi-center clinical. And the random number was generated by SAS9.1.3 into two experimental groups (4 grains, 120 cases and 6 grains, 120 cases), and control group (120 cases). The experimental group was treated with Yaotongning Capsules for 4 weeks, and the control group was treated with Yaobitong Capsules for 4 weeks. At 0 day, 2, and 4 weeks, the VAS score, Oswestry dysfunction index, and onset time of pain were evaluated, and the efficacy and safety of the treatment were evaluated. Results: After 4 weeks of treatment, the efficacy of ODI grade showed that the excellent rates of the experimental group (4 grains), control group, and experimental group (6 grains) were 85.83%, 73.95%, and 85%, the efficacy of the experimental group (4 grains) was better than other groups, and the adverse reaction was the least. However, in terms of pain relief and improvement in the ODI scale, the experimental group (6 grains) in 2 and 4 weeks after treatment of In VAS and ODI improvement experiment, the decreased value of experimental group (6 grains) > experimental group (4 grains) > control group. Conclusion: Yaotongning Capsules in the treatment of lumbar disc herniation (cold dampness and blood stasis syndrome) have obviously curative effect and good safety, and have the advantage of the rapid relief of pain and could improve the function of lumbar spine.