Effect of Weichang'an Pill on motilin in functional dyspepsia in liver stagnation and spleen deficiency rats / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 3673-3676, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-853222
ABSTRACT
Objective:
To observe the effect of Weichang'an Pill on regulating the gastrointestinal motility and plasma motilin (MTL) level in liver stagnation and spleen deficiency type of functional dyspepsia (FD) rat model.Methods:
Sixty rats were randomly divided into six groups (n = 10) control group, model group, Weichang'an pill high (50.4 mg/kg), medium(25.2 mg/kg) and low (12.6 mg/kg) dose (middle dose for clinical equivalent dose) groups, Domperidone Tablets group as positive control group, all groups were intragastric administered for 7 d. The gastric remnant rate and plasma MTL level in rats were measured after administration.Results:
The gastric residual rate in Weichang'an pill high dose group and Domperidone Tablets group decreased significantly compared with the model group (P < 0.05); The plasma MTL levels in Weichang'an pill high dose group were significantly increased compared with the control group and model group (P < 0.05). The plasma MTL in Weichang'an pill dose group was significantly higher than that of model group (P < 0.05).Conclusion:
Weichang'an Pill can regulate the MTL level so that improve gastric motility and furthermore play a therapeutic effect on FD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2016
Type:
Article
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