Chemical constituents in lindenane-type sesquiterpene dimers in roots of Chloranthus multistachys / 中草药

ABSTRACT

Objective: To study the chemical constituents contained in the ethanol extracts from the roots of Chloranthus multistachys. Methods: Twelve compounds were separated from the roots of C. multistachys and their structures were identified by using various chromatographic techniques. Results: The structures of the 12 lindenane-type sesquiterpene dimmers from the chloroform and ethyl acetate extract in the roots of C. multistachys were identified on the basis of physicochemical properties and spectral data as 9-O-β-glucopyranosylcycloshizukaol A (1), cycloshizukaol A (2), shizukaol B (3), shizukaol C (4), shizukaol D (5), shizukaol F (6), shizukaol G (7), chloramultiol B (8), sarcandrolide B (9), sarglabolide I (10), 8-O-methyltianmushanol (11), and henriol B (12). Conclusion: Compounds 1, 7, and 9-12 are isolated from the roots C. multistachys for the first time and compounds 9 and 10 are obtained from the plants of Chloranthus Sw. for the first time.