Fragmentation pathways of six aconitine alkaloids using HPLC-Q-TOF-MS technology / 中草药
Chinese Traditional and Herbal Drugs
; (24): 2827-2831, 2016.
Article
in Zh
| WPRIM
| ID: wpr-853332
Responsible library:
WPRO
ABSTRACT
Objective: To study the fragmentation pathways of six aconitine-type alkaloids (aconitine, hypaconitine, mesaconitine, benzoylaconitine, benzoylhypaconitine, and benzoylmesaconitine) in mass spectra (MS). Methods: The samples were analyzed by liquid chromatography-tandem quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). Results: In positive mode, The typical fragmentation pathways of the six aconitine-type alkaloids were mainly continuous loss of CH3OH and H2O. The characteristic fragmentation pathway of diester-diterpene type aconitine was losing an acetic acid molecule from C-8 position; However this fragmentation could not be observed in MS of mono-ester aconitine alkaloids. Conclusion: The study on fragmentation pathways could be adopted for the structural identification of the six aconitine-type alkaloids.
Full text:
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Index:
WPRIM
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Chinese Traditional and Herbal Drugs
Year:
2016
Type:
Article