Effect of administration temperature on efficacy of Gegen Qinlian Decoction on DSS-induced ulcerative colitis in rats / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 2897-2901, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-853345
ABSTRACT
Objective:
To observe the effect of the administration temperature of GQD on the efficacy to ulcerative colitis (UC) of rats.Methods:
The GQD was given to dextran sulfate sodium (DSS)-induced UC rats at different temperature (10℃/42℃) for 7 d. The disease activity index (DAI), histopathological score of colon, superoxide dismutase (SOD), malondialdehyde (MDA), GHS-Px, myeloperoxidase (MPO) of serum and colon tissue, and the tumor necrosis factor (TNF-α) of serum were measured and observed.Results:
Compared with the control group, the UC relative symptom and index changes of rats in the model group appeared obviously. GQD showed the significant therapeutic effects in both 10℃ and 42℃ groups. The lower temperature administration achieved significantly better results than the higher one on the histopathological score, colon wall thickness, and biochemical indices.Conclusion:
The cold GQD shows higher efficacy than the hot GQD when treating UC, which may be attributed to the immune response of intestinal mucosal mast cells to temperature-induced stress.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2016
Type:
Article
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