Research progress in pharmacological mechanism of ginkgolides against cerebral ischemia / 中草药

ABSTRACT

Cerebral ischemia is a severe disease which threats people's health worldwide. The pathogenesis of cerebral ischemia is very complex, such as inflammatory reaction, apoptosis, oxidative stress, excitatory neurotoxicity, etc. Previous studies suggested that ginkgolides had a remarkable protective effect against the different types of brain injury including ischemia and tissue regeneration and repair. This review summarizes the targets of ginkgolides for cerebral ischemia treatments and the potential mechanisms. Compared with the commonly used drugs in clinic, we expect to clarify the mechanism of ginkgolides and their preparations in the treatment of cerebral ischemia.