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Comparation on effects of Moutan Cortex, Paeoniae Rubra Radix, and Paeoniae Alba Radix on acute blood stasis model rats / 中草药
Chinese Traditional and Herbal Drugs ; (24): 2676-2683, 2016.
Article in Chinese | WPRIM | ID: wpr-853370
ABSTRACT

Objective:

To investigate the effects of Moutan Cortex, Paeoniae Rubra Radix, and Paeoniae Alba Radix on the acute blood stasis model rats, and reveal their mechanism and differences in efficacy.

Methods:

The actue blood stasis model of rats was induced by sc injecting adrenaline hydrochloride and soaking in ice water. Salvia Injection was used as the positive control drug. The changes of viscosity of whole blood and plasma, thrombin activity, blood platelet system, and the contents of TXB2 and 6-keto-PGF1α were detected in the acute blood stasis model rats.

Results:

Compared with the model group, Moutan Cortex obviously extended PT, and TT (P < 0.05), inhibited platelet adhesion rate (P < 0.01), reduced TXB2 (P < 0.01), increased 6-keto-PGF1α in serum (P < 0.01), and regulated eNOS and p-eNOS expression (P < 0.01, 0.001). Paeoniae Rubra Radix significantly improved whole blood viscosity at different shear rates, extended APTT, TT, and PT (P < 0.05, 0.01), reduced platelet adhesion rate (P < 0.05), decreased TXB2, increased 6-keto-PGF1α in serum (P < 0.01), and increased eNOS and p-eNOS expression (P < 0.05). Paeoniae Alba Radix had no significant effect on hemorheology, but could significantly prolong APTT and TT (P < 0.05), reduce platelet adhesion rate (P < 0.05), increase the content of 6-keto-PGF1α in serum (P < 0.05) and increase the eNOS and p-eNOS expression in platelet.

Conclusion:

All Moutan Cortex, Paeoniae Rubra Radix, and Paeoniae Alba Radix have varying degrees on hemorheology, coagulation system, platelet system, but Moutan Cortex and Paeoniae Rubra Radix have the better role in promoting blood circulation compared with Paeoniae Alba Radix.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional and Herbal Drugs Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional and Herbal Drugs Year: 2016 Type: Article